Ger Millerick replaces David Griffin in the Cork defence for Saturday's All-Ireland U21HC semi-final clash with Wexford at Nowlan Park.
Fr O'Neill's clubman Millerick, a minor in 2017, will line out at full-back in the absence of the injured Griffin. This is the only change from last month's impressive 2-23 to 1-13 Munster final win over Tipperary.
Denis Ring has named six players, who featured in the All-Ireland SHC semi-final extra-time defeat to Limerick on Sunday, in his starting 15, namely Mark Coleman, Darragh Fitzgibbon, Robbie O'Flynn, Shane Kingston, Tim O'Mahony and Jack O'Connor.
Cork (All-Ireland U21HC v Wexford): Ger Collins; Seadnaidh Smyth, Niall O'Leary, Ger Millerick; Eoghan Murphy, Mark Coleman, Billy Hennessy; David Lowney, Darragh Fitzgibbon; Robbie O'Flynn, Declan Dalton, Shane Kingston; Liam Healy, Tim O'Mahony, Jack O'Connor.
Subs: Shane Hurley, Chris O'Leary, John Cashman, Eoin Roche, Daire Connery, Conor Cahalane, Micheal O'Halloran, Aaron Myers, Conor O'Callaghan, Stephen Condon.